Maritssia Abdelshiheed¹, Arushi Gupta², Jalyn Huang³#

¹ Woodbridge High School

² Irvine High School

³ Irvine High School

#Advisor

ABSTRACT

Chronic inflammation is a central feature in many disorders, ranging from autoimmune diseases to autoinflammatory conditions such as Chronic Recurrent Multifocal Osteomyelitis (CRMO).

The main findings emphasize that chronic immune dysregulation plays a critical role in disease development, with CRMO serving as an important example of how innate immune dysfunction manifests clinically. Current diagnostic approaches, such as whole-body MRI, and available treatment options, including nonsteroidal anti-inflammatory drugs and biologic therapies, have improved outcomes but remain limited in scope.

By situating CRMO within the larger framework of inflammation and immune-mediated disease, this research underscores the importance of continued investigation into underlying mechanisms, improved diagnostic strategies, and novel therapeutic approaches.

This paper explores the fundamental components of the immune system, the processes of inflammation, and the progression from acute to chronic states that can drive disease.

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